Third Covid vaccine shot excessive precedence for the immune-deficient

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Federal health officials are working “as soon as possible” to approve a third Covid-19 vaccine for Americans with compromised immune systems, said Dr. White House chief physician Anthony Fauci on Thursday.

It is now clear that such people – including cancer and HIV patients or those who have received an organ transplant – generally fail to produce adequate immune responses after receiving two doses of a Covid vaccine, Fauci said.

“Immunocompromised people are vulnerable,” said Fauci during a briefing at the White House. “It is extremely important for us to give these people their boosters and we are working on it now and we will make sure that this is done asap. … It is a very high priority.”

Immunocompromised populations make up only about 2.7% of the adult US population. Still, they account for about 44% of hospitalized breakthrough Covid cases – an infection in a fully vaccinated person, according to recent data from an advisory group from the Centers for Disease Control and Prevention.

Anthony Fauci, director of the National Institute for Allergies and Infectious Diseases, listens during a hearing of the Senate Funds Subcommittee in Washington, DC, on Jan.

Stefani Reynolds | Swimming pool | Reuters

Studies suggest that a third shot might help people whose immune systems don’t respond as well to a first or second dose.

Four small studies cited by the CDC last month showed that 16% to 80% of people with compromised immune systems had no detectable antibodies to Covid after two shots. Among immunocompromised patients who had no detectable antibody response, 33 to 50% developed an antibody response after receiving an additional dose, according to the CDC.

“It now appears from observational data that they are generally not giving an adequate response that we believe would be adequately protected,” Fauci said Thursday.

Other countries such as France are already giving third vaccinations to people with cancer or other immune deficiencies. Israel announced last month that it would offer booster syringes to people over the age of 60 as the syringe seems to be becoming less effective in these people.

Some doctors have pushed for the US to allow an extra dose to immunocompromised populations, and many immunocompromised Americans are already finding extra doses of the vaccines, medical experts say.

Dr. Scott Gottlieb, who headed the Food and Drug Administration during the Trump administration from 2017 to 2019, told CNBC on Monday that he believes the elderly and immunocompromised people will receive booster vaccinations through September or October.

Disclosure: Scott Gottlieb is a CNBC employee and a member of the board of directors of Pfizer, genetic testing startup Tempus, health technology company Aetion Inc., and biotechnology company Illumina. He is also co-chair of the Healthy Sail Panel of Norwegian Cruise Line Holdings and Royal Caribbean.

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