When researchers look at glutathione levels in these studies, they often ask the question: Does oxidative stress play a role in this particular disorder?
Oxidative stress is the unfavorable ratio of antioxidants to free radicals, and glutathione is a marker of oxidative stress. When your glutathione is low, it means it was used to fight free radicals.
For me the most important question is: if more glutathione were available, would the problem be averted? We don't know the answer to that at the moment, although I hope it will be fixed in the future.
Many different factors can be involved in depression and anxiety. These include a dysfunction of the brain chemicals serotonin and dopamine. Some researchers believe that glutathione helps dopamine become more effective in the brain and increases sensitivity to serotonin.
If so – and it has not yet been proven – glutathione may one day be used to treat depression. Right now I don't know many doctors who treat either anxiety or depression with GSH. However, as we learn more about the relationship between oxidative stress and mental disorders, we may find that glutathione plays an important role.