Psilocybin and Neuroplasticity – Tim Cools

Psilocybin and Neuroplasticity - Tim Cools

Any man, if so inclined, could be the sculptor of his own brain. "

– Santiago Ramón y Cajal, Nobel Prize Winner of the Spanish Neuroscientist

Neuroplasticity, also known as brain plasticity or neural plasticity, is the brain's ability to change continuously throughout your life.

While for decades it was believed that our brains were a non-renewable organ and that brain cells are given in a finite amount and slowly die as we age. We now know that the brain can create new connections and pathways and change the wiring of its circuits.

During such changes, the brain participates in synaptic pruning, clearing the neural connections that are no longer necessary or useful, and strengthening those that are necessary. This process can be influenced by inputs of your emotions, behaviors, experiences and even thoughts.

For example, people suffering from depression or stress-related illnesses often have fewer connections or fewer total neurons in certain parts of the brain.

There are two main types of neuroplasticity:

  • Structural neuroplasticity, in which the strength of the connections between neurons (or synapses) changes.
  • Functional neuroplasticity, in which the synapses are constantly changing due to learning and development, resulting in changes in the actual structure of the brain.

Both types offer exciting abilities, and a study by researchers from the University of California showed that serotonergic psychedelics, including psilocin, help neuritogenesis (new growth of neurons), spinogenesis (growth of spines on neurons), and synaptogenesis (the formation of synapses between Neurons), thereby promoting both forms of neuroplasticity.

This partly explains the therapeutic potential of magic truffles. Not only to treat various neuropsychiatric disorders, but also by offering potential avenues for psychological change, e.g. B. “open up the possibility of reinventing yourself and moving away from the status quo, or overcoming past traumatic events that arouse fear and stress. ”(Christopher Bergland)

And of course that's good news.

Above: Functional connectivity of a normal brain (a) compared to a brain with psilocybin (b).

Inspired to learn more about psychedelics? Check out my What are Psychedelics? What does science say Items.

If you are interested in a personalized psilocybin retreat please take a look at the Truffle Transformation Experience.


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